3-Chloro-2-methylbenzenesulfonyl chloride → HCID 10158142, compound

HRID 719327Notes

Reaction equation

HRID 719327 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[C:15]([CH3:24])=[C:16]([S:20]([NH:12][C:9]2[S:10][CH:11]=[C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:8]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 7017824-(5-Chlorothiophen-2-yl)-1,3-thiazol-2-amine

Product 1

HCID 10158142HCID 10158142, compound

Procedure

The title compound was prepared from 4-(5-chloro-2-thienyl)-1,3-thiazol-2-amine and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a beige solid (29.9 mg) with purity >90%: MS (pos) m/z 405.0, 407.0; HRMS m/z 403.9278 (calc. of monoisotopic mass for C14H10Cl2N2O2S3 gives 403.9281).

Sources & evidence

ORD record
ord-f5085ab834bc4c5daefbf744799524ed
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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