(1,1'-Biphenyl)-4-sulphonyl chloride → N-(4-{2-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}phenyl)acetamide

HRID 719332Notes

Reaction equation

HRID 719332 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=2)[N:6]=1.[C:17]1([C:23]2[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:23]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:28]=[CH:27][C:26]([S:29]([NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:11][CH:12]=3)[N:6]=2)(=[O:31])=[O:30])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 519881N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide

Product 1

HCID 10182341N-(4-{2-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}phenyl)acetamide

Procedure

The title compound was prepared N-[4-(2-amino-1,3 -thiazol-4-yl)phenyl]acetamide and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (8.6 mg) with purity >80%. MS (pos) m/z 450.3.

Sources & evidence

ORD record
ord-5cca1f59d5f6406899ceb6fd157bdb1d
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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