4-(3-Chloro-2-thienyl)-1,3-thiazol-2-amine → HCID 10274951, compound

HRID 719346Notes

Reaction equation

HRID 719346 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[Cl:1])[N:8]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 14884414-(3-Chloro-2-thienyl)-1,3-thiazol-2-amineHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 10274951HCID 10274951, compound

Procedure

The title compound was prepared from 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (9.4 mg) with purity >90%: MS (pos) m/z 439.1, 441.1; HRS m/z 437.8875 (calc. of monoisotopic mass for C14H9Cl3N2O2S3 gives 437.8892).

Sources & evidence

ORD record
ord-146beaaec28f47d2b1d038b40ab60e58
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

Loading…