2,4,5-Trichlorobenzenesulfonyl chloride → 2,4,5-Trichloro-N-[4-(3-chloro-2-thienyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719350Notes

Reaction equation

HRID 719350 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([Cl:21])=[CH:16][C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[C:17]([Cl:21])=[CH:16][C:15]=1[S:22]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:3]2[S:4][CH:5]=[CH:6][C:2]=2[Cl:1])[N:8]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chlorideHCID 14884414-(3-Chloro-2-thienyl)-1,3-thiazol-2-amine

Product 1

HCID 101616502,4,5-Trichloro-N-[4-(3-chloro-2-thienyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine (59 mg) and 2,4,5-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a white solid (9.2 mg) with purity >90%: MS (pos) m/z 459.2, 461.2, 463.2.

Sources & evidence

ORD record
ord-7ad6317c35944b9c939b3c1ecb08240f
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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