2,4,5-Trichlorobenzenesulfonyl chloride → N-[4-(2-{[(2,4,5-Trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

HRID 719355Notes

Reaction equation

HRID 719355 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=2)[N:6]=1.[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[C:21]([Cl:25])=[CH:20][C:19]=1[S:26](Cl)(=[O:28])=[O:27]>>[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[C:21]([Cl:25])=[CH:20][C:19]=1[S:26]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:11][CH:12]=2)[N:6]=1)(=[O:28])=[O:27]

Participants

3

Reactant 2

HCID 275752,4,5-Trichlorobenzenesulfonyl chlorideHCID 519881N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide

Product 1

HCID 10277267N-[4-(2-{[(2,4,5-Trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

Procedure

The title compound was prepared from N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide (63 mg) and 2,4,5-trichlorobenzenesulfonyl chloride (76 mg) as described in the synthetic METHOD B to give a white-yellow solid (5,0 mg) with purity >90%: MS (pos) m/z 476.3. 478.3.

Sources & evidence

ORD record
ord-d99c75a2a297400f8780e70a4160c1a1
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

Loading…