4-(3-Chloro-2-thienyl)-1,3-thiazol-2-amine → HCID 10299227, compound

HRID 719357Notes

Reaction equation

HRID 719357 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Br:13][C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[S:17][C:18]=1[Cl:19]>>[Br:13][C:14]1[CH:15]=[C:16]([S:20]([NH:12][C:9]2[S:10][CH:11]=[C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])[N:8]=2)(=[O:22])=[O:21])[S:17][C:18]=1[Cl:19]

Participants

3

Reactant 2

HCID 14884414-(3-Chloro-2-thienyl)-1,3-thiazol-2-amineHCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chloride

Product 1

HCID 10299227HCID 10299227, compound

Procedure

The title compound was prepared from 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine (59 mg) and 4-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (34.2 mg) with purity >90%: MS (pos) m/z 457.1, 477.1, 479.1.

Sources & evidence

ORD record
ord-a3acaac8b8f14541a41016c2e96e7d76
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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