3-Bromo-5-chlorothiophene-2-sulfonyl chloride → 3-Bromo-5-chloro-N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)-2-thiophenesulfonamide

HRID 719358Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 719358
Br.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH2:14])[S:13][C:9]=1[CH2:8][CH2:7]2.[Br:18][C:19]1[CH:23]=[C:22]([Cl:24])[S:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26]>>[Br:18][C:19]1[CH:23]=[C:22]([Cl:24])[S:21][C:20]=1[S:25]([NH:14][C:12]1[S:13][C:9]2[CH2:8][CH2:7][C:6]3[C:15](=[CH:16][CH:17]=[C:4]([O:3][CH3:2])[CH:5]=3)[C:10]=2[N:11]=1)(=[O:27])=[O:26]

Komponenten

3

Edukt 2

HCID 27374003-Bromo-5-chlorothiophene-2-sulfonyl chlorideHCID 28074737-Methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine hydrobromide

Produkt 1

HCID 101635393-Bromo-5-chloro-N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)-2-thiophenesulfonamide

Versuchsvorschrift

The title compound was prepared 7-methoxy-4,5-dihydronaphtho(1,2-D)(1,3)thiazol-2-amine hydrobromide (85 mg) and 3-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (17.8 mg) with purity >80%: MS (pos) m/z 491.3, 493.3.

Quellen und Nachweise

ORD-Eintrag
ord-539256eb67a9429590a9b69e8d4f7a16
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07132436B2

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