4-Bromo-2,5-difluorobenzenesulfonyl Chloride → HCID 10209980, compound

HRID 719365Notes

Reaction equation

HRID 719365 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[C:13]1[N:14]=[C:15]([NH2:18])[S:16][CH:17]=1.[Br:19][C:20]1[C:25]([F:26])=[CH:24][C:23]([S:27](Cl)(=[O:29])=[O:28])=[C:22]([F:31])[CH:21]=1>>[Br:19][C:20]1[C:25]([F:26])=[CH:24][C:23]([S:27]([NH:18][C:15]2[S:16][CH:17]=[C:13]([C:3]3[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:9])([F:11])[F:10])=[CH:5][C:4]=3[Cl:12])[N:14]=2)(=[O:28])=[O:29])=[C:22]([F:31])[CH:21]=1

Participants

3

Reactant 2

HCID 5745904-Bromo-2,5-difluorobenzenesulfonyl ChlorideHCID 628563HCID 628563, compound

Product 1

HCID 10209980HCID 10209980, compound

Procedure

The title compound was prepared 4-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine (85 mg) and 4-bromo-2,5-difluorobenzenesulfonyl chloride (79 mg) as described in the synthetic METHOD B to give a white solid (38.2 mg) with purity >90%: MS (pos) m/z 567.2, 569.2, 571.2; MS (neg) m/z 565.5, 567.5, 569.5.

Sources & evidence

ORD record
ord-ceedfb2b9789401c964732e6ea4260a2
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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