N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide → N-[4-(2-{[(4-Bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

HRID 719367Notes

Reaction equation

HRID 719367 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:9][CH:8]=2)[N:6]=1.[Br:17][C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[S:21][C:22]=1[Cl:23]>>[Br:17][C:18]1[CH:19]=[C:20]([S:24]([NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([NH:13][C:14](=[O:16])[CH3:15])=[CH:11][CH:12]=3)[N:6]=2)(=[O:26])=[O:25])[S:21][C:22]=1[Cl:23]

Participants

3

Reactant 2

HCID 519881N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamideHCID 27972204-Bromo-5-chlorothiophene-2-sulfonyl chloride

Product 1

HCID 10163602N-[4-(2-{[(4-Bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide

Procedure

The title compound was prepared N-[4-(2-amino-1,3-thiazol-4-yl)phenyl}acetamide (63 mg) and 4-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (11.7 mg) with purity >80%: MS (pos) m/z 491.9, 493.9.

Sources & evidence

ORD record
ord-09ec76ce30cb45bb8034ff91b9d41c58
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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