HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide → N-[4-(2-{[(4-Bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)acetamide | HCID 519881 | — |
| Reactant | 4-Bromo-5-chlorothiophene-2-sulfonyl chloride | HCID 2797220 | — |
| Product | N-[4-(2-{[(4-Bromo-5-chloro-2-thienyl)sulfonyl]amino}-1,3-thiazol-4-yl)phenyl]acetamide | HCID 10163602 | — |
Reaction Steps
The title compound was prepared N-[4-(2-amino-1,3-thiazol-4-yl)phenyl}acetamide (63 mg) and 4-bromo-5-chlorothiophene-2-sulfonyl chloride (80 mg) as described in the synthetic METHOD B to give a white solid (11.7 mg) with purity >80%: MS (pos) m/z 491.9, 493.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132436B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-09ec76ce30cb45bb8034ff91b9d41c58 |
| Source note | uspto-grants-2006_11 |