4-N-Propylbenzenesulphonyl chloride → N-(4,5-dihydrothieno[3,2-e][1,3]benzothiazol-2-yl)-4-propylbenzenesulfonamide

HRID 719371Notes

Reaction equation

HRID 719371 reaction equation
[N:1]1[C:5]2[C:6]3[CH:12]=[CH:11][S:10][C:7]=3[CH2:8][CH2:9][C:4]=2[S:3][C:2]=1[NH2:13].[CH2:14]([C:17]1[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1)[CH2:15][CH3:16]>>[N:1]1[C:5]2[C:6]3[CH:12]=[CH:11][S:10][C:7]=3[CH2:8][CH2:9][C:4]=2[S:3][C:2]=1[NH:13][S:23]([C:20]1[CH:21]=[CH:22][C:17]([CH2:14][CH2:15][CH3:16])=[CH:18][CH:19]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 27372224-N-Propylbenzenesulphonyl chlorideHCID 218981955,10-Dithia-3-azatricyclo[7.3.0.0,2,6]dodeca-1(9),2(6),3,11-tetraen-4-amine

Product 1

HCID 10135012N-(4,5-dihydrothieno[3,2-e][1,3]benzothiazol-2-yl)-4-propylbenzenesulfonamide

Procedure

The title compound was prepared from 4,5-dihydrothieno[3,2-e][1,3]benzothiazol-2-amine (105 mg, synthesized according to METHOD I from 4-keto-4,5,6,7-tetrahydrothianaphthene) and 4-n-propylbenzenesulfonyl chloride (111 mg) as described in the synthetic METHOD A to give a white powder (18 mg) with a purity >90%: MS-ES (neg) m/z 389.3.

Sources & evidence

ORD record
ord-9ace31efa6e34e51bd0989f6522abf32
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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