4-N-Propylbenzenesulphonyl chloride → HCID 10274239, compound

HRID 719375Notes

Reaction equation

HRID 719375 reaction equation
[N+:1]([C:4]1[CH:17]=[C:16]2[C:7]([CH2:8][CH2:9][C:10]3[S:14][C:13]([NH2:15])=[N:12][C:11]=32)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:18]([C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1)[CH2:19][CH3:20]>>[N+:1]([C:4]1[CH:17]=[C:16]2[C:7]([CH2:8][CH2:9][C:10]3[S:14][C:13]([NH:15][S:27]([C:24]4[CH:25]=[CH:26][C:21]([CH2:18][CH2:19][CH3:20])=[CH:22][CH:23]=4)(=[O:29])=[O:28])=[N:12][C:11]=32)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 27372224-N-Propylbenzenesulphonyl chlorideHCID 9992165HCID 9992165, compound

Product 1

HCID 10274239HCID 10274239, compound

Procedure

The title compound was prepared from 8-nitro-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine (100 mg, synthesized according to METHOD I from 7-nitrotetralone) and 4-n-propylbenzenesulfonyl chloride (106 mg) as described in the synthetic METHOD A to give a yellow powder (3.5 mg) with a purity of 87%: MS-ES (neg) m/z 428.4.

Sources & evidence

ORD record
ord-b7abef8e53e3452ba49924e6e542c658
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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