N,N-Dimethylaniline → 4-Chloro-1-[4-(methanesulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine

HRID 719447Notes

Reaction equation

HRID 719447 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15]3=[N:16][CH:17]=[N:18][C:19](O)=[C:14]3[CH:13]=[N:12]2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].CN(C)C1C=CC=CC=1.O=P(Cl)(Cl)[Cl:32]>>[Cl:32][C:19]1[N:18]=[CH:17][N:16]=[C:15]2[N:11]([C:8]3[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=3)[N:12]=[CH:13][C:14]=12

Participants

4

Reactant 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 178504785HCID 178504785, compound

Product 1

HCID 218974474-Chloro-1-[4-(methanesulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidineYield 27%

Procedure

Into a 50 mL round-bottomed equipped with a reflux condenser and N2 inlet septum was place a stir bar, 1-(4-methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ol (93 mg, 0.32 mmol), dimethylaniline (0.3 mL) and POCl3 (10 mL). The reaction mixture was stirred at room temperature under N2 for 5 minutes and brought to reflux for 6 hrs. After cooling down to room temperature, the reaction mixture was poured into ice and extracted with CH2Cl2 quickly. The crude product was then purified by flash chromatography (EtOAc: Hex=1:1), 24 mg of product was obtained (27% yield). 1H NMR (DMSO-d6, 400 MHz) δ 3.29 (s, 3H), 8.19 (d, 2H), 8.53 (d, 2H), 8.89 (s, 1H), 9.08 (s, 1H). LCMS calculated C12H9ClN4O2S 308.01, observed 309.1 (MH+).

Workup

  1. customInto a 50 mL round-bottomed equipped with a reflux condenser and N2 inlet septum
  2. temperatureto reflux for 6 hrs
  3. temperatureAfter cooling down to room temperature
  4. additionthe reaction mixture was poured into ice
  5. extractionextracted with CH2Cl2 quickly
  6. customThe crude product was then purified by flash chromatography (EtOAc: Hex=1:1)

Sources & evidence

ORD record
ord-86c48c14151a48de80831914c4dc6891
Source dataset
uspto-grants-2006_11
Patent number
US07132426B2

Reaction notes

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