HCID 11340732, compound → HCID 11429113, compound

HRID 719499Notes

Reaction equation

C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[CH:19][N:18]=[C:17]3[N:21]([C:24]4[CH:29]=[CH:28][C:27]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:26][CH:25]=4)[N:22]=[CH:23][C:16]=23)[CH2:10][CH2:9]1)(C)(C)C>Cl.O1CCOCC1>[CH3:33][S:30]([C:27]1[CH:28]=[CH:29][C:24]([N:21]2[C:17]3=[N:18][CH:19]=[N:20][C:15]([NH:14][CH:11]4[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]4)=[C:16]3[CH:23]=[N:22]2)=[CH:25][CH:26]=1)(=[O:32])=[O:31]

Participants

Conditions

Temperature: 40 °C

Procedure

{4-[1-(4-Methanesulfonyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino]-cyclohexyl}-carbamic acid tert-butyl ester (30 mg, 0.06 mmol) was dissolved in 4M HCl in dioxane (2 mL) and then stirred overnight at 40° C. The resulting solution was evaporated to provide compound A54 as a white solid (24 mg, 100%). Exact mass calculated for C18H22N6O2S 386.2, found 387.2(MH+).

Workup

customThe resulting solution was evaporated

Sources & evidence

ORD record: ord-711c2d9a367346ab8456dc316b3f9b00
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07132426B2

Reaction notes

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