HCID 86760292, compound → HCID 178441597, compound

HRID 719561Notes

Reaction equation

HRID 719561 reaction equation
[CH:1]1([CH2:7][C:8]2[N:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4N4C=NN=N4)=[CH:20][CH:19]=3)[N:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:35]1[CH:39]=[N:38][N:37]=[N:36]1>>[CH:1]1([CH2:7][C:8]2[N:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[C:39]4[NH:38][N:37]=[N:36][N:35]=4)=[CH:20][CH:19]=3)[N:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 86760292HCID 86760292, compoundHCID 178418441HCID 178418441, compound3×

Product 1

HCID 178441597HCID 178441597, compound

Procedure

The slower moving isomer from Example 73 was deprotected to provide 51 mg of 5-[4′-[(3-cyclohexylmethyl-5-butyl-1H-1,2,4-triazol-1-yl)methyl]([1,1-biphenyl]-2-yl]-1H-tetrazole as a colorless solid: NMR (CDCl3) δ 0.84 (t, J=8 Hz, 3H), 0.92 (q, J=8 Hz, 2H), 1.05–1.22 (m, 3H), 1.22–1.36 (m, 2H), 1.52–1.69 (m, 8H), 2.5–0 (d, J=7 Hz, 2H), 2.63 (t, J=8 Hz, 2H), 5.18 (s, 2H), 7.05 (q, J=8 Hz, 4H), 7.35–7.55 (m, 3H), 7.68 (dd, J=8 and 2 Hz, 1H); MS (FAB) m/e (rel intensity) 456 (90), 413 (10), 281 (10), 243 (10), 222 (35), 207 (100), 192 (35); HRMS. Calc'd for M+H: 456.2876. Found: 456.2849.

Sources & evidence

ORD record
ord-65f5bc7cb9a042da97c7fe6881dbd220
Source dataset
uspto-grants-2006_11
Patent number
US07132437B2

Reaction notes

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