HCID 86760292, compound → HCID 178441597, compound

Participants

Reaction Steps

The slower moving isomer from Example 73 was deprotected to provide 51 mg of 5-[4′-[(3-cyclohexylmethyl-5-butyl-1H-1,2,4-triazol-1-yl)methyl]([1,1-biphenyl]-2-yl]-1H-tetrazole as a colorless solid: NMR (CDCl3) δ 0.84 (t, J=8 Hz, 3H), 0.92 (q, J=8 Hz, 2H), 1.05–1.22 (m, 3H), 1.22–1.36 (m, 2H), 1.52–1.69 (m, 8H), 2.5–0 (d, J=7 Hz, 2H), 2.63 (t, J=8 Hz, 2H), 5.18 (s, 2H), 7.05 (q, J=8 Hz, 4H), 7.35–7.55 (m, 3H), 7.68 (dd, J=8 and 2 Hz, 1H); MS (FAB) m/e (rel intensity) 456 (90), 413 (10), 281 (10), 243 (10), 222 (35), 207 (100), 192 (35); HRMS. Calc'd for M+H: 456.2876. Found: 456.2849.

Provenance & Evidence