Hydrochloric Acid → Methyl 4-nitro-L-phenylalaninate hydrochloride

HRID 719662Notes

Reaction equation

HRID 719662 reaction equation
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:16].[CH3:17]O>>[ClH:16].[CH3:17][O:12][C:11](=[O:13])[C@H:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=1)[NH2:10]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137064-Nitro-3-phenyl-L-alanine

Product 1

HCID 11715866Methyl 4-nitro-L-phenylalaninate hydrochlorideYield 85%

Procedure

4-Nitrophenylalanine (1) (24 mmol) was treated with methanol (100 ml) saturated with HCl (g) and left to stir at room temperature for 18 hours. The solution was concentrated by evaporating to ⅓ of original volume and the precipitate was collected and dried under vacuum for 18 hours. The yield was 85%.

Workup

  1. waitleft
  2. concentrationThe solution was concentrated
  3. customby evaporating to ⅓ of original volume
  4. customthe precipitate was collected
  5. customdried under vacuum for 18 hours

Sources & evidence

ORD record
ord-770ef3718ddd4673842d4166dd361184
Source dataset
uspto-grants-2006_11
Patent number
US07132513B2

Reaction notes

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