反应详情

To a THF (200 mL) solution containing 3-(4-fluorophenyl)propanoic acid (33.6 g, 0.2 mol) was added a 1.0 M solution of LiAlH4 in Et2O (200 mL, 0.2 mol) over a period of 0.5 h. The resulting mixture was allowed to stir at RT for 18 h. The reaction was slowly quenched with H2O and the aqueous layer extracted (1×) with Et2O. The combined organic extracts were dried over MgSO4 and concentrated in vacuo. The resulting oil was used in the next step without further purification. Isolated 31.4 g (0.2 mol, 100% yield).

1. customThe reaction was slowly quenched with H2O
2. extractionthe aqueous layer extracted (1×) with Et2O
3. dry with materialThe combined organic extracts were dried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe resulting oil was used in the next step without further purification
6. customIsolated 31.4 g (0.2 mol, 100% yield)