1-(4-Nitrophenyl)pyrrolid-3-yl methanesulphonate → 1'-(4-Nitrophenyl)[1,3]bipyrrolidinyl

Participants

Reaction Steps

5 g (0.0174 mol) of 1-(4-nitrophenyl)pyrrolid-3-yl methanesulphonate (2) were heated at 85° C. for 2 hours in 30 ml of pyrrolidine (mol). This mixture was poured into ice-cold water until crystallization takes place. After filtration and drying, the yellow powder obtained was chromatographed, eluting with dichloromethane/methanol (98/2), and 2.6 g of derivative (5) were recovered (53% yield).

Provenance & Evidence