反应详情

5 g (0.0174 mol) of 1-(4-nitrophenyl)pyrrolid-3-yl methanesulphonate (2) were heated at 85° C. for 2 hours in 30 ml of pyrrolidine (mol). This mixture was poured into ice-cold water until crystallization takes place. After filtration and drying, the yellow powder obtained was chromatographed, eluting with dichloromethane/methanol (98/2), and 2.6 g of derivative (5) were recovered (53% yield).

1. additionThis mixture was poured into ice-cold water until crystallization
2. filtrationAfter filtration
3. customdrying
4. customthe yellow powder obtained
5. customwas chromatographed
6. washeluting with dichloromethane/methanol (98/2), and 2.6 g of derivative (5)
7. customwere recovered (53% yield)