反应详情

2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid was synthesized as described for 4′-(2-phenoxy-ethylsulfanylmethyl)-biphenyl-3-carboxylic acid. 2′-(2-Phenoxy-ethylsulfanylmethyl)-biphenyl-2-carboxylic acid ethyl ester (4.4 g, 11.21 mmol, 1 eq.) in 30% aqueous THF/dioxane was treated with lithium hydroxide (0.81 g, 33.63 mmol, 3 eq.). When complete, the reaction was worked up as described leaving a brown oil

1. customas described leaving a brown oil