Citric Acid → HCID 21887943, compound

HRID 719834Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34]>>[C:31]([OH:43])(=[O:42])[CH2:32][C:33]([CH2:38][C:39]([OH:41])=[O:40])([C:35]([OH:37])=[O:36])[OH:34].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 311Citric Acid

HCID 21887313HCID 21887313, compound

Product 1

HCID 21887943HCID 21887943, compound

Procedure

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2 (1H)-one hydrochloride (205 mg, 0.5 mmol) obtained in Example 39 and citric acid (96 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (278 mg) having a melting point of 100 to 102° C. (dec).

Sources & evidence

ORD record: ord-bbd3419cf185448a8aeb9a898e59fa20
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07132547B2

Reaction notes

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