Hydrochloric Acid → (3-Chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid

Temperature

50 °C

A solution of (3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid methyl ester (61.7 g, 252 mmol) in toluene (120 mL) was heated at 50° C. This heated solution was then treated dropwise with a 3M aqueous sodium hydroxide solution (105 mL, 315 mmol) via a dropping funnel, taking care to keep the temperature below 60° C. After the addition was complete, the reaction mixture was stirred at 50° C. for another 1.5 h, during which time, a yellow precipitate began to form. After this time, the heat was removed, and the warm solution was treated dropwise with concentrated hydrochloric acid (10.6 mL, 290 mmol). The resulting reaction mixture was allowed to cool to 25° C. and then was stirred at 25° C. for 16 h. The solid was filtered and then washed with water (50 mL) and toluene (50 mL). The solid was dried by suction for 1 h and then dried in a high vacuum desiccator to afford (3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid (57.22 g, 98%) as a white solid: mp 166° C. (dec); FAB-HRMS m/e calcd for C9H7ClO3S (M+Na)+ 252.9702, found 252.9700.

1. customthe temperature below 60° C
2. additionAfter the addition
3. customto form
4. customAfter this time, the heat was removed
5. customThe resulting reaction mixture
6. temperatureto cool to 25° C.
7. stirringwas stirred at 25° C. for 16 h
8. filtrationThe solid was filtered
9. washwashed with water (50 mL) and toluene (50 mL)
10. customThe solid was dried by suction for 1 h
11. customdried in a high vacuum desiccator

ORD record

ord-e9826d54398548dab0292afd309a72ac

Source dataset

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07132425B2