HCID 67482685, compound → HCID 21897377, compound

HRID 719946Notes

Reaction equation

HRID 719946 reaction equation
C(OC(=O)[NH:10][C:11]1[CH:16]=[N:15][C:14]([CH2:17][CH:18]([O:21][CH3:22])[O:19][CH3:20])=[CH:13][N:12]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:22][O:21][CH:18]([O:19][CH3:20])[CH2:17][C:14]1[N:15]=[CH:16][C:11]([NH2:10])=[N:12][CH:13]=1

Participants

4

Reactant 1

HCID 67482685HCID 67482685, compound

Product 1

HCID 21897377HCID 21897377, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 5-(2,2-dimethoxy-ethyl)-pyrazin-2-yl-carbamic acid benzyl ester (130 mg, 0.4096 mmol) in methanol (5 mL) was treated with 10% palladium on activated carbon (30 mg). The reaction mixture was then hydrogenated under a hydrogen atmosphere at 25° C. and atmospheric pressure for 60 min, The mixture was filtered through celite, and the filtrate was concentrated in vacuo to afford 5-(2,2-dimethoxy-ethyl)-pyrazin-2-ylamine (75 mg, 100%) as a pale yellow oil.

Workup

  1. customwas then hydrogenated under a hydrogen atmosphere at 25° C.
  2. filtrationThe mixture was filtered through celite
  3. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-f999d898e4d04427821db918bd29ebf7
Source dataset
uspto-grants-2006_11
Patent number
US07132425B2

Reaction notes

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