3-Hydroxypyridine → HCID 21901945, compound

HRID 720031Notes

Reaction equation

HRID 720031 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].O1C2C=CC(O[CH2:24][CH:25]3[CH2:30][CH2:29][CH2:28][N:27]([C:31]([C:33]4([C:37]5[CH:42]=[CH:41][C:40]([Cl:43])=[CH:39][CH:38]=5)[CH2:36][CH2:35][CH2:34]4)=[O:32])[CH2:26]3)=CC=2OC1>>[Cl:43][C:40]1[CH:41]=[CH:42][C:37]([C:33]2([C:31]([N:27]3[CH2:28][CH2:29][CH2:30][CH:25]([CH2:24][O:1][C:2]4[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=4)[CH2:26]3)=[O:32])[CH2:36][CH2:35][CH2:34]2)=[CH:38][CH:39]=1

Participants

4

Reactant 3

HCID 79713-HydroxypyridineHCID 10796Cesium carbonateHCID 21902076HCID 21902076, compound

Product 1

HCID 21901945HCID 21901945, compound

Procedure

Compound 85 was synthesized from 3-hydroxypyridine (0.25 g, 2.60 mmol), cesium carbonate (1.27 g, 3.89 mmol) and compound 43 (1.0 g, 2.60 mmol), using the method described for the synthesis of compound 44 to give 0.52 g of the desired product 85. C22H25ClN2O2, LRMS (m/z)=385 (MH+).

Sources & evidence

ORD record
ord-3007a5c6c84c4381b52d1b4f5c99e12c
Source dataset
uspto-grants-2006_11
Patent number
US07132551B2

Reaction notes

Loading…