Trifluoroacetic acid → HCID 137242022, compound

HRID 720080Notes

Reaction equation

HRID 720080 reaction equation
C(O[C:6](=O)[N:7](C)[CH2:8][C:9](=[O:31])[NH:10][C:11]1[CH:12]=[C:13]2[C:29](=[O:30])[NH:28][N:27]=[CH:26][C:15]3=[C:16]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[NH:17][C:18]([CH:19]=1)=[C:14]23)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>C(Cl)Cl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[CH3:6][NH:7][CH:8]([CH3:35])[C:9]([NH:10][C:11]1[CH:12]=[C:13]2[C:29](=[O:30])[NH:28][N:27]=[CH:26][C:15]3=[C:16]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[NH:17][C:18]([CH:19]=1)=[C:14]23)=[O:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136181617HCID 136181617, compound

Product 1

HCID 137242022HCID 137242022, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound of Example 19 (19 mg, 0.042 mmol) in CH2Cl2 (0.65 mL) was treated with trifluoroacetic acid (0.45 mL) and allowed to stir for 0.5 hours. The volatile components were removed under vacuum, and diethyl ether was added and evaporated three times to give the title compound (19 mg, 0.041 mmol) as a yellow, orange powder in 98% yield.

Workup

  1. customThe volatile components were removed under vacuum, and diethyl ether
  2. additionwas added
  3. customevaporated three times

Sources & evidence

ORD record
ord-98463e4c936544388536b394a92f1f45
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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