Trifluoroacetic acid → HCID 137242023, compound

HRID 720090Notes

Reaction equation

HRID 720090 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:36])[NH:15][C:16]2[CH:17]=[C:18]3[C:34](=[O:35])[NH:33][N:32]=[CH:31][C:20]4=[C:21]([C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=5)[NH:22][C:23]([CH:24]=2)=[C:19]34)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>C(Cl)Cl>[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[O:35]=[C:34]1[C:18]2[C:19]3[C:20](=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[NH:22][C:23]=3[CH:24]=[C:16]([NH:15][C:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:36])[CH:17]=2)[CH:31]=[N:32][NH:33]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136181610HCID 136181610, compound

Product 1

HCID 137242023HCID 137242023, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation of example 31 from the title compound of Example 29 (20 mg, 0.041 mmol) and 45% TFA in CH2Cl2 (1 mL) was carried out analogously to Example 20. Isolation, also in an analogous manner, afforded the title compound (20 mg, 0.040 mmol) as a yellow powder in 97% yield.

Sources & evidence

ORD record
ord-69d3094ce2344f5c913627b8f51886d5
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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