HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | (1r,2r)-2-Phenyl-cyclopropanecarboxylic acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide | HCID 136141630 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt | HCID 137241993 | — |
Reaction Steps
The title compound of Example 83a (0.075 g, 0.16 mmol) in dichloromethane (1.0 mL) was treated with 4M HCl in dioxane (0.043 mL, 0.17 mmol). After concentrating to dryness, the title compound (0.08 g) was obtained in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132533B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-6fea764fc9f746a7aa6bf59eedbadf45 |
| Source note | uspto-grants-2006_11 |