Hydrochloric Acid → (1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt

HRID 720119Notes

Reaction equation

HRID 720119 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13]3[CH:14]=[C:15]([NH:25][C:26]([C@@H:28]4[CH2:30][C@H:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:27])[CH:16]=[C:17]4[C:23](=[O:24])[NH:22][N:21]=[CH:20][C:19]=2[C:18]=34)[CH:8]=[CH:9][CH:10]=1)[CH3:3].[ClH:37].O1CCOCC1>ClCCl>[ClH:37].[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([C:11]2[NH:12][C:13]3[CH:14]=[C:15]([NH:25][C:26]([C@@H:28]4[CH2:30][C@H:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)=[O:27])[CH:16]=[C:17]4[C:23](=[O:24])[NH:22][N:21]=[CH:20][C:19]=2[C:18]=34)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 136141630(1r,2r)-2-Phenyl-cyclopropanecarboxylic acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide

Product 1

HCID 137241993(1R,2R)-2-Phenyl-cyclopropanecarboxylic Acid [2-(3-dimethylaminomethyl-phenyl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-amide HCl Salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound of Example 83a (0.075 g, 0.16 mmol) in dichloromethane (1.0 mL) was treated with 4M HCl in dioxane (0.043 mL, 0.17 mmol). After concentrating to dryness, the title compound (0.08 g) was obtained in quantitative yield.

Workup

  1. concentrationAfter concentrating to dryness

Sources & evidence

ORD record
ord-6fea764fc9f746a7aa6bf59eedbadf45
Source dataset
uspto-grants-2006_11
Patent number
US07132533B2

Reaction notes

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