Trifluoroacetic acid → HCID 21901733, compound

HRID 720193Notes

Reaction equation

HRID 720193 reaction equation
C(OC(=O)[NH:7][CH:8]([CH2:27][C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)[C:9]([N:11]1[CH2:15][CH:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:13][CH:12]1[CH2:24][CH:25]=[CH2:26])=[O:10])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:24]([CH:12]1[CH2:13][CH:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:15][N:11]1[C:9](=[O:10])[CH:8]([NH2:7])[CH2:27][C:28]1[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=1)[CH:25]=[CH2:26]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69587774HCID 69587774, compound

Product 1

HCID 21901733HCID 21901733, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[2-(2-Allyl-4-benzyloxy-pyrrolidin-1-yl)-1-(4-fluorobenzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester, 53, (0.67 g, 1.4 mmol) is dissolved in methylene chloride (21 mL), and trifluoroacetic acid (9 mL) is added. The reaction mixture is stirred for 1 hourr and then concentrated in vacuo. MeOH (40 mL) is added and the solvent is removed in vacuo to afford the desired product in approximately quanitative yield as a viscous oil which is used without further purification.

Workup

  1. concentrationconcentrated in vacuo
  2. additionMeOH (40 mL) is added
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-75dd793d028e40a68db80e59d5828d7a
Source dataset
uspto-grants-2006_11
Patent number
US07132539B2

Reaction notes

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