Water → HCID 21889076, compound

HRID 720211Notes

Reaction equation

HRID 720211 reaction equation
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH2:11][CH2:12][CH2:13][CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.O>CS(C)=O>[N:15]1([CH2:14][CH2:13][CH2:12][NH:11][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[CH:3]=2)[CH:19]=[CH:18][N:17]=[CH:16]1

Participants

5

Reactant 3

HCID 962WaterHCID 98231-Fluoro-3-nitrobenzeneHCID 787361H-Imidazole-1-propanamine

Product 1

HCID 21889076HCID 21889076, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

28.2 g 3-fluoronitrobenzene and 137.5 g 1-(3-aminopropyl)imidazole were dissolved in 300 ml dimethyl sulfoxide, and the batch was stirred for 60 h at 100° C. After cooling, the batch was poured into 1 l water. The precipitated product was suction-filtered and dried overnight under vacuum.

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitated product was suction-filtered
  3. customdried overnight under vacuum

Sources & evidence

ORD record
ord-61b9d81092d04804a2c2bcf8b1c8c151
Source dataset
uspto-grants-2006_11
Patent number
US07135047B2

Reaction notes

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