Methanol → 1-Methoxy-2-dodecanol
Reaction equation
[CH3:1][OH:2].[O:3]1[CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:4]1>>[CH3:1][O:2][CH2:4][CH:5]([OH:3])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]Participants
3
Conditions
- Temperature
- 60 °C
Procedure
The same reactor that was used in Production Example 5 was charged with 64 g (2 mol) of methanol and 2 g of boron trifluoride diethyl ether complex and then the mixture was raised to 60° C. Then, 184.3 g (1 mol) of 1,2-epoxydodecane was added dropwise to the mixture over one hour and the resulting mixture was kept as it was for 3 hours. The reaction was terminated just after confirming that 1,2-epoxydodecane left unreacted was less than 1% by gas chromatography and then the reaction mixture was cooled. Thereafter, methanol was removed in the same manner as in Production Example 5 to obtain 2-hydroxydodecyl methyl ether.
Workup
- customThe reaction was terminated just
- waitleft unreacted
- temperaturethe reaction mixture was cooled
- customThereafter, methanol was removed in the same manner as in Production Example 5
Sources & evidence
- ORD record
- ord-db80ebc7b88445a794e1d3f12f9b1ff2
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07135443B2
Reaction notes
Loading…