Ammonium formate → HCID 69204653, compound

HRID 720385Notes

Reaction equation

HRID 720385 reaction equation
C([N:14]1[CH2:17][CH:16]([CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=3)[N:21]([CH3:29])[CH:20]=2)[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd]>[NH:14]1[CH2:17][CH:16]([CH2:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=3)[N:21]([CH3:29])[CH:20]=2)[CH2:15]1

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 69206079HCID 69206079, compound

Product 1

HCID 69204653HCID 69204653, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

This compound was prepared as described for Intermediate 31, using 3-(1-benzhydryl-azetidin-3-ylmethyl)-5-fluoro-1-methyl-1H-indole (0.37 g, 0.94 mmol), palladium on carbon (10%, ˜0.1 g) and ammonium formate (0.24 g, 2.8 mmol), to afford 0.18 g of the title compound as a clear oil. The oxalate was prepared in ethanol and collected as a white solid, m.p. 155–156° C.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-70864ee3069047ec8cc095174a67e685
Source dataset
uspto-grants-2006_11
Patent number
US07135479B2

Reaction notes

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