反应详情

A mixture of 3-(1-benzhydryl-azetidin-3-ylmethyl)-1H-indole-5-carbonitrile (8) (0.56 g, 1.5 mmol), palladium on carbon (10%, 0.1 g) and ammonium formate (0.37 g, 5.9 mmol) in ethanol (20 ml) was refluxed for 2 hours. The mixture was filtered through celite and the solvent removed under vacuum. Diphenylmethane was removed by triturating the residue with ether, methylene chloride and decanting. The remaining product was dried under vacuum. The crude material was directly used in next step. MS ES m/e 200 (M+H)+.

1. temperaturewas refluxed for 2 hours
2. filtrationThe mixture was filtered through celite
3. customthe solvent removed under vacuum
4. customDiphenylmethane was removed
5. customby triturating the residue with ether, methylene chloride
6. customdecanting
7. customThe remaining product was dried under vacuum