Methyl Isocyanate → HCID 135828227, compound

HRID 720455Notes

Reaction equation

HRID 720455 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:20][CH2:21][NH2:22])[N:3]=1.[CH3:23][N:24]=[C:25]=[O:26]>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:20][CH2:21][NH:22][C:25]([NH:24][CH3:23])=[O:26])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 135828224HCID 135828224, compound

Product 1

HCID 135828227HCID 135828227, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

62.2 mg (0.2 mmol) of 2-amino-6-[(2-aminoethyl)sulfanyl]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile are suspended in 0.4 ml of DMF, and 11.4 mg (0.2 mmol) of methyl isocyanate are added at room temperature. The mixture is stirred overnight, filtered and purified by preparative HPLC.

Workup

  1. filtrationfiltered
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-4ab6f198e32d4ab7831c98bc5ab53375
Source dataset
uspto-grants-2006_11
Patent number
US07135486B1

Reaction notes

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