Ethyl isocyanate → HCID 135828227, compound

HRID 720456Notes

Reaction equation

HRID 720456 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:20][CH2:21][NH2:22])[N:3]=1.[CH2:23]([N:25]=[C:26]=[O:27])C>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:20][CH2:21][NH:22][C:26]([NH:25][CH3:23])=[O:27])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 135828224HCID 135828224, compound

Product 1

HCID 135828227HCID 135828227, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

62.2 mg (0.2 mmol) of 2-amino-6-[(2-aminoethyl)sulfanyl]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile are suspended in 0.4 ml of DMF, and 14.2 mg (0.2 mmol) of ethyl isocyanate are added at room temperature. The mixture is stirred overnight, filtered and purified by preparative HPLC.

Workup

  1. filtrationfiltered
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-5a5ac934757246f78a52d747b79b75f3
Source dataset
uspto-grants-2006_11
Patent number
US07135486B1

Reaction notes

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