3-Bromopyridine → HCID 86591298, compound

HRID 720471Notes

Reaction equation

HRID 720471 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[O:8]=[C:9]1[C@@H:16]2[C@@H:12]([CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15]2)[CH2:11][CH2:10]1>>[OH:8][C:9]1([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[C@@H:16]2[C@@H:12]([CH2:13][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:15]2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 29948688rel-1,1-Dimethylethyl (3aR,6aS)-hexahydro-4-oxocyclopenta[c]pyrrole-2(1H)-carboxylate

Product 1

HCID 86591298HCID 86591298, compoundYield 27%

Procedure

3-Bromopyridine (4.36 g, 27.6 mmol) and the product from Example 44A (2.07 g, 9.19 mmol) were processed as described in Example 1E to afford the title compound (0.743 g, 27%). MS (DCI/NH3) m/z 305 (M+H)+

Sources & evidence

ORD record
ord-10ff8feac28343bcaf077713c7794a0e
Source dataset
uspto-grants-2006_11
Patent number
US07135484B2

Reaction notes

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