Formate → N-(2-Fluorophenyl)formamide
Reaction equation
[CH:1]([O-:3])=O.C(OC(=O)C)(=O)C.[F:11][C:12]1[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=1[NH2:14]>O1CCCC1>[CH:1]([NH:14][C:13]1[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=1[F:11])=[O:3]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
Under argon gas, formate (6.1 mL) was added to acetic anhydride (15.5 mL) at 0° C. and the mixture was stirred at 50° C. for 2 hours. The reaction mixture was cooled to room temperature and diluted with tetrahydrofuran (10 mL). Tetrahydrofuran (20 mL) solution containing 2-fluoroaniline (5.56 g) was added into the diluent at room temperature and stirred at room temperature for 1 hour. A title compound having the following physical properties was obtained by concentrating the reaction mixture. The obtained title compound was used for the following reaction without further purification.
Workup
- temperatureThe reaction mixture was cooled to room temperature
- additionwas added into the diluent at room temperature
- stirringstirred at room temperature for 1 hour
Sources & evidence
- ORD record
- ord-2d560a71f11640ad8ca8ccc85ad0afbc
- Source dataset
- uspto-grants-2006_11
- Patent number
- US07135495B2
Reaction notes
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