Trifluoroacetic acid → HCID 10482184, compound

HRID 720650Notes

Reaction equation

HRID 720650 reaction equation
C([O:5][CH2:6][CH:7]1[C:11](=[O:12])[N:10]([C:13]2[CH:42]=[CH:41][C:16]([CH2:17][C:18]3[NH:26][C:25]4[C:24](=[O:27])[N:23]([CH2:28][C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=5[F:35])[C:22](=[O:36])[N:21]([CH2:37][CH:38]5[CH2:40][CH2:39]5)[C:20]=4[N:19]=3)=[CH:15][CH:14]=2)[C:9](=[O:43])[NH:8]1)(C)(C)C.FC(F)(F)C(O)=O>>[CH:38]1([CH2:37][N:21]2[C:20]3[N:19]=[C:18]([CH2:17][C:16]4[CH:41]=[CH:42][C:13]([N:10]5[C:11](=[O:12])[C@H:7]([CH2:6][OH:5])[NH:8][C:9]5=[O:43])=[CH:14][CH:15]=4)[NH:26][C:25]=3[C:24](=[O:27])[N:23]([CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[F:35])[C:22]2=[O:36])[CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21891699HCID 21891699, compound

Product 1

HCID 10482184HCID 10482184, compound

Procedure

8-[4-(4-tert-Butoxymethyl-2,5-dioxo-imidazolidin-1-yl)-benzyl]-3-cyclopropylmethyl-1-(2-fluorobenzyl)-3,7-dihydro-purine-2,6-dione was treated with trifluoroacetic acid (2 mL). After stirring at room temperature for 2 h, the reaction was concentrated and the residue was purified by reverse phase HPLC. LCMS, m/z(M+H)=533.12.

Workup

  1. concentrationthe reaction was concentrated
  2. customthe residue was purified by reverse phase HPLC

Sources & evidence

ORD record
ord-a29129aa4e514a938d58c84b19936bb5
Source dataset
uspto-grants-2006_11
Patent number
US07135475B2

Reaction notes

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