Potassium Hydroxide → HCID 10457781, compound

HRID 720651Notes

Reaction equation

[C:1]([NH:4][C:5]1[CH:6]=[C:7]([NH:35]C(=O)C)[CH:8]=[CH:9][C:10]=1[CH2:11][C:12]1[NH:20][C:19]2[C:18](=[O:21])[N:17]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[F:29])[C:16](=[O:30])[N:15]([CH2:31][CH2:32][CH2:33][CH3:34])[C:14]=2[N:13]=1)(=[O:3])[CH3:2].[OH-].[K+]>>[NH2:35][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][C:12]2[NH:20][C:19]3[C:18](=[O:21])[N:17]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[F:29])[C:16](=[O:30])[N:15]([CH2:31][CH2:32][CH2:33][CH3:34])[C:14]=3[N:13]=2)=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[CH:6]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 44427026N,N′-[4-[[3-Butyl-1-[(2-fluorophenyl)methyl]-2,3,6,9-tetrahydro-2,6-dioxo-1H-purin-8-yl]methyl]-1,3-phenylene]bis[acetamide]

Product 1

HCID 10457781HCID 10457781, compound

Procedure

Prepared from N-{3-acetylamino-4-[3-butyl-1-(2-fluorobenzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-acetamide by refluxing with 20% aqueous potassium hydroxide. The product was purified by chromatography using silica eluted with 92:8 chloroform/methanol. MS, m/z(M+)=478.2132.

Workup

customThe product was purified by chromatography
washeluted with 92:8 chloroform/methanol

Sources & evidence

ORD record: ord-24fbe581c818492bb944dcad393ae7f6
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07135475B2

Reaction notes

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