Hydrochloric Acid → HCID 135774035, compound

HRID 720693Notes

Reaction equation

HRID 720693 reaction equation
[ClH:1].[Br:2][C:3]1[C:4]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[N:5][N:6]2[CH:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH2:10][CH:9]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[NH:8][C:7]=12.O.C[Si]([Cl:39])(C)C>C(C(C)=O)C>[ClH:39].[ClH:1].[Br:2][C:3]1[C:4]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[N:5][N:6]2[CH:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=3)[CH2:10][CH:9]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[NH:8][C:7]=12

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 135774033HCID 135774033, compound

Product 1

HCID 135774035HCID 135774035, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To form the hydrochloride 139 mg of 3-bromo-7-(3,4-dimethoxyphenyl)-2-phenyl-5-pyridin-2-yl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine were dissolved in 1.1 ml of methyl ethyl ketone and then 6 μl of H2O and 7 μl of TMSCl were added. After some time a solid precipitated out. After suction filtration and washing with ether, yellow crystals were obtained that were dried under a vacuum.

Workup

  1. customAfter some time a solid precipitated out
  2. filtrationAfter suction filtration
  3. washwashing with ether
  4. customyellow crystals were obtained
  5. customthat were dried under a vacuum

Sources & evidence

ORD record
ord-a3adda228bc14ee78a3bc9c9ab2c8dd3
Source dataset
uspto-grants-2006_11
Patent number
US07135568B2

Reaction notes

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