HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 86591596, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | Glycine tert-butyl ester | HCID 151417 | — |
| Reactant | 3-((Pyridin-2-yl)amino)propan-1-ol | HCID 11412479 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86591596 | HCID 86591596 | — |
Reaction Steps
2.6 ml of diisopropylethylamine are added to a solution of 0.9 g of 3-(pyridin-2-ylamino)propan-1-ol in 3 ml of N,N-dimethylformamide. This solution is subsequently added dropwise to a solution of 1 g of 4-nitrophenyl chloroformate in 10 ml of dichloromethane. After the mixture has been stirred at room temperature for 1 hour, 0.7 g of tert-butyl aminoacetate and 0.8 ml of DIPEA are added, and the mixture is stirred for a further 2 hours. Conventional work-up gives tert-butyl [3-(pyridin-2-ylamino)propoxycarbonylamino]acetate, Rf=0.488 (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07135587B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-5ecae82c28364910b621791158732cc8 |
| Source note | uspto-grants-2006_11 |