反应详情

2.6 ml of diisopropylethylamine are added to a solution of 0.9 g of 3-(pyridin-2-ylamino)propan-1-ol in 3 ml of N,N-dimethylformamide. This solution is subsequently added dropwise to a solution of 1 g of 4-nitrophenyl chloroformate in 10 ml of dichloromethane. After the mixture has been stirred at room temperature for 1 hour, 0.7 g of tert-butyl aminoacetate and 0.8 ml of DIPEA are added, and the mixture is stirred for a further 2 hours. Conventional work-up gives tert-butyl [3-(pyridin-2-ylamino)propoxycarbonylamino]acetate, Rf=0.488 (ethyl acetate).

1. stirringthe mixture is stirred for a further 2 hours