Phosphorus oxychloride → HCID 15118080, compound

HRID 720831Notes

Reaction equation

HRID 720831 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9]([O-:12])(=O)=[O:10])[CH:5]=[CH:6][CH:7]=1.[Na+].P(Cl)(Cl)([Cl:16])=O>S1(CCCC1)(=O)=O.C(#N)C>[I:1][C:2]1[CH:3]=[C:4]([CH2:8][S:9]([Cl:16])(=[O:12])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 86609640HCID 86609640, compound

Product 1

HCID 15118080HCID 15118080, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 31347SulfolaneSolvent

Procedure

A stirred mixture of sodium (3-iodophenyl)methanesulfonate (3.6 g) and phosphoryl chloride (10 ml) in sulpholane (20 ml) and acetonitrile (30 ml) was heated at 70° for 2 h. The mixture was poured onto crushed ice (200 ml) and the precipitated product was collected and dried to give the title product (2.8 g) LCMS RT=3.47 min.

Workup

  1. temperaturewas heated at 70° for 2 h
  2. additionThe mixture was poured
  3. customthe precipitated product was collected
  4. customdried

Sources & evidence

ORD record
ord-85750d35bac24d49b21177a461b77aec
Source dataset
uspto-grants-2006_11
Patent number
US07135600B2

Reaction notes

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