反应详情

温度

70 °C

Piperidine-3-carboxylic acid [4-phenyl-1-(3-phenyl-propyl)-butyl]-amide (13) (150 mg; 0.4 mmol) is dissolved in isopropanol (10 mL) at ambient temperature. tert-Butyl[S-(R*, R*)]-(−)-(1-oxiranyl)-2-phenylethyl)carbamate (104.4 mg; 0.4 mmol) is added, then the mixture is heated to 70° C. and maintained for 18 hours. After cooling to ambient temperature, the solution is concentrated in vacuo at 40° C. The residue is purified via silica gel chromatography with gradient elution (1%→20% methanol in methylene chloride) affording the desired product (166.7 mg) as an oil. ESMS:MH+ 642.6 (base).

1. temperaturemaintained for 18 hours
2. temperatureAfter cooling to ambient temperature
3. concentrationthe solution is concentrated in vacuo at 40° C
4. customThe residue is purified via silica gel chromatography with gradient elution (1%→20% methanol in methylene chloride)