N-(2-Aminoethyl)piperidine → HCID 58658629, compound

HRID 720941Notes

Reaction equation

HRID 720941 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[C:13]3[C:14]([O:22][CH3:23])=[C:15]([O:20][CH3:21])[C:16]([O:18][CH3:19])=[CH:17][C:12]=3[CH2:11][CH2:10][C@H:9]([NH:24][C:25](=[O:27])[CH3:26])[C:8]=2[CH:28]=1)([OH:3])=O.[NH2:29][CH2:30][CH2:31][N:32]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[C:25]([NH:24][C@@H:9]1[C:8]2[CH:28]=[C:4]([C:1]([NH:29][CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)=[O:3])[CH:5]=[CH:6][C:7]=2[C:13]2[C:14]([O:22][CH3:23])=[C:15]([O:20][CH3:21])[C:16]([O:18][CH3:19])=[CH:17][C:12]=2[CH2:11][CH2:10]1)(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 33944N-(2-Aminoethyl)piperidineHCID 16114799HCID 16114799, compound

Product 1

HCID 58658629HCID 58658629, compoundYield 43%

Procedure

Using an analogous procedure to that described for Example 10, N-[(5S)-3-carboxy-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide was reacted with 1-(2-aminoethyl)piperidine to give (5S)-5-(acetylamino)-9,10,11-trimethoxy-N-(2-piperidinoethyl)-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-3-carboxamide.

Sources & evidence

ORD record
ord-4f9daa01394b40f3b2770e78abbdadfb
Source dataset
uspto-grants-2006_11
Patent number
US07135502B1

Reaction notes

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