Hydrochloric Acid → HCID 58658619, compound

HRID 720955Notes

Reaction equation

HRID 720955 reaction equation
[P:1]([O:35]C(C)(C)C)([O:30]C(C)(C)C)([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14]3[C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=3[CH2:12][CH2:11][C@H:10]([NH:25][C:26](=[O:28])[CH3:27])[C:9]=2[CH:29]=1)=[O:2].Cl>O1CCOCC1>[P:1]([OH:30])([OH:35])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14]3[C:15]([O:23][CH3:24])=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=3[CH2:12][CH2:11][C@H:10]([NH:25][C:26](=[O:28])[CH3:27])[C:9]=2[CH:29]=1)=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58658572HCID 58658572, compound

Product 1

HCID 58658619HCID 58658619, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using an analogous procedure to that described for Example 27 [(5S)-5-(acetylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl]methyl ditertbutyl phosphate was treated with 1M hydrogen chloride in 1,4-dioxane to give [(5S)-5-(acetylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl]methyl dihydrogen phosphate.

Sources & evidence

ORD record
ord-99a7789dbced4ee28d984250257cc56f
Source dataset
uspto-grants-2006_11
Patent number
US07135502B1

Reaction notes

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