HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Amino-4-butoxybenzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Amino-4-butoxybenzoic acid | HCID 20217440 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 2-Amino-4-butoxybenzoic acid methyl ester | HCID 68975401 | — |
Reaction Steps
A mixture of 2-amino-4-butoxybenzoic acid (2.0 g), thionyl chloride (1.2 g) and methanol (33 mL) was boiled under reflux for 24 hours. The reaction solution was diluted with MTBE and washed with sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 223.27 (C12H17NO3) was obtained in this way; MS (ESI): 224 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828991B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3a6f1e3e35b4485ba1d75418a662e72b |
| Source note | uspto-grants-2014_09 |