反应详情

A mixture of 2-amino-4-butoxybenzoic acid (2.0 g), thionyl chloride (1.2 g) and methanol (33 mL) was boiled under reflux for 24 hours. The reaction solution was diluted with MTBE and washed with sodium hydroxide solution. The organic phase was dried and concentrated. The product with the molecular weight of 223.27 (C12H17NO3) was obtained in this way; MS (ESI): 224 (M+H+).

1. temperatureunder reflux for 24 hours
2. washwashed with sodium hydroxide solution
3. customThe organic phase was dried
4. concentrationconcentrated
5. customThe product with the molecular weight of 223.27 (C12H17NO3) was obtained in this way