反应详情

A solution of 3-tert-butoxycarbonylamino-5-(5-fluoropyridin-2-yl)-thiophene-2-carboxylic acid methyl ester (80 mg) in dichloromethane (1.35 mL) was mixed with trifluoroacetic acid (0.15 mL) and stirred at room temperature overnight. The solvent was then removed in vacuo, and the residue was taken up again in dichloromethane and washed twice with saturated NaHCO3 solution and once with water. The dichloromethane phase was dried over sodium sulfate and concentrated. The product with the molecular weight of 252.27 (C11H9FN2O2S) was obtained in this way; MS (ESI): 253 (M+H+).

1. customThe solvent was then removed in vacuo
2. washwashed twice with saturated NaHCO3 solution and once with water
3. dry with materialThe dichloromethane phase was dried over sodium sulfate
4. concentrationconcentrated
5. customThe product with the molecular weight of 252.27 (C11H9FN2O2S) was obtained in this way